THE DEVELOPMENT OF GLYCOBIOLOGY-BASED THERAPEUTICS FOR THE TREATMENT OF BRAIN TUMORS

摘要

A unique panel of differentially expressed glioma-associated genes is identified, as well as a unique and differentially expressed panel of non-glioma associated genes. Disclosed are methods for selecting gene-targeted therapeutic agents for the treatment and inhibition of glioblastoma, as well as anti-glioblastoma therapeutics themselves. Molecular constructs, such as adenoviral vectors, that include selected of the identified differentially expressed glioma associated genes and/or non-glioma associated genes are also provided. A focused oligonucleotide microarray of highly glioma specific oligonucleotide sequences is also provided. Microchips and/or other solid and semi-solid support matrices that include the oligonucleotides attached thereto are also provided. Methods for diagnosing glioblastoma in a patient are also provided employing a genetic microarray comprising the oligonucleotide sequences.