BILE SALT COLLOIDS AND METHODS OF MAKING AND USING THEREOF

摘要

Particulate compositions containing an active agent in combination with a bile salt or a polymer of a bile salt are described herein. The active agent may be the bile salt or polymer thereof. In one embodiment, the active agent is encapsulated in, coated onto, or incorporated into a matrix forming a polymeric microparticle or nanoparticle. The bile salt can be coated onto the surface of the particle or incorporated into a coating which is coated onto the surface of the particle. In another example, polymeric microparticles having active agent encapsulated therein can be dispersed in a bile salt emulsion. Alternatively, the bile salt can be incorporated into the polymeric microparticle or nanoparticle, for example, dispersed throughout the polymeric microparticle or nanoparticle or encapsulated in the core, where active agent(s) is in the core, the polymeric matrix, the coating, or a combination thereof. Active agent can be encapsulated in the core and/or can be dispersed throughout the microparticle. In another embodiment, the active agent is encapsulated in a microparticle, coating, layer, core, emulsion or dispersion formed of a polymer of a bile salt, such as polydeoxycholic acid. Suitable active agents include therapeutic, diagnostic, and/or prophylactic agents. The compositions are formulated for oral administration or administration to a mucosal (nasal, pulmonary, rectal, vaginal, buccal, sublingual).