发明名称 |
17ß-HSD1 and STS inhibitors |
摘要 |
The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17ß-hydroxysteroid dehydrogenase type I (17ß-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17ß-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17ß-estradiol concentration. |
申请公布号 |
ZA200709854(B) |
申请公布日期 |
2009.03.25 |
申请号 |
ZA20070009854 |
申请日期 |
2006.05.24 |
申请人 |
SOLVAY PHARMACEUTICALS GMBH |
发明人 |
MESSINGER, JOSEF;THOLE, HEINRICH-HUBERT;HUSEN, BETTINA;KOSKIMIES, PASI;PIRKKALA, LILA;WESKE, MICHAEL |
分类号 |
A61K;A61P;C07J |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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