发明名称 |
SALTS OF PYRROLOPYRIMIDINONE DERIVATIVES AND PROCESS FOR PREPARING THE SAME |
摘要 |
The present invention relates to salts of a pyrrolopyrimidinone derivative having superior PDE-5 inhibition activity and a process for preparing the same. More particularly, the present invention relates to a crystalline acid addition salt prepared by reacting a pyrrolopyrimidinone derivative with an acid selected from gentisic acid, maleic acid, citric acid, fumaric acid and tartaric acid. With no hygroscopic property and superior long-term storage stability, photostability and thermal stability, the salts of the pyrrolopyrimidinone derivative are appropriate to be prepared into medications and, with superior PDE-5 inhibition activity, are useful for the treatment and prevention of erectile dysfunction, pulmonary arterial hypertension, chronic obstructive pulmonary disease, benign prostatic hypertrophy and lower urinary tract diseases. |
申请公布号 |
EP2038282(A1) |
申请公布日期 |
2009.03.25 |
申请号 |
EP20070768581 |
申请日期 |
2007.07.03 |
申请人 |
SK CHEMICALS, CO., LTD. |
发明人 |
KIM, JAE-SUN;KIM, NAM HO;LEE, JIN YOUNG;LEE, NAM KYU;LEE, YOON-JUNG;JANG, WOO JAE;YOUN, WON-NO;OH, JOON GYO;SUNG, JIN-HEUNG;UM, KEY AN |
分类号 |
C07D487/04;A61K31/522 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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