发明名称 |
CELL DIFFERENTIATION INHIBITING AGENT, CELL CULTURE METHOD USING THE SAME, CULTURE MEDIUM AND CULTURED CELL LINE |
摘要 |
The object of the present invention is to provide a differentiation inhibiting agent which allows culture of a stem cell or an embryonic stem cell in an undifferentiated state without use of any feeder cell, a method for culturing using the same, a cell culture liquid using the same, and a cell prepared by culturing using this differentiation inhibiting agent. The present invention provides a differentiation inhibiting agent which comprises a low molecular weight compound, especially a tetrahydroisoquinoline derivative, as an active ingredient; a method for safely culturing a stem cell in large scale in undifferentiated state in the absence of feeder cell which comprises culturing a stem cell by using a tetrahydroisoquinoline derivative; a culture liquid for stem cells comprising a tetrahydroisoquinoline derivative; and a cell which is obtained by culture using a tetrahydroisoquinoline derivative as a differentiation inhibiting agent. |
申请公布号 |
EP1640449(A4) |
申请公布日期 |
2009.03.25 |
申请号 |
EP20040746848 |
申请日期 |
2004.06.25 |
申请人 |
ASAHI KASEI KABUSHIKI KAISHA |
发明人 |
MIYABAYASHI, TOMOYUKI;YAMAMOTO, MASASHI |
分类号 |
C12N5/06;A61K31/404;A61K31/47;A61K31/472;A61K31/655;A61P1/02;A61P1/16;A61P3/10;A61P9/10;A61P9/12;A61P17/02;A61P19/02;A61P19/10;A61P25/00;A61P25/02;A61P25/16;A61P25/28;A61P27/02;A61P29/00;C07C209/04;C07D217/16;C12N5/00 |
主分类号 |
C12N5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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