BETA-SECRETASE INHIBITING COMPOUNDS

摘要

A pharmaceutical composition including a compound for beta-secretase inhibition is provided to prevent and treat a neurodegenerative disease. A pharmaceutical composition comprises a compound represented by the formula 1. The compound realizes a function of beta-secretase inhibition. In the formula 1, n is 0~2 and A is represented by the formual 2. In the formula 2, W, X, Y and Z are independently carbon atom or one or two nitrogen atoms; R1 is -(CR6R7)m-R8, wherein m is 0~2, R6 is selected from the group consisting of hydrogen, alkyl and alkoxy, and R7 is selected from the group consisting of hydrogen, alkyl and - C(O)NHR6.