PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS

摘要

This invention describes novel protein kinase inhibitors of formula (VII): wherein G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Rind C has one or two ortho substituents independently selected from -R1; Ri ng D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Ry is T-R3"; T is a valence bond or a C1-4 alkylidene chain; R3" is an optionally substituted group selected from C1-6 alphatic, C3-10 carbocyclyl, C6-10 aryl, a heteroar yl ring having 5-10 ring atoms; and R1, R2, and R2' are as described in the specification. The protein kinase are useful for treating diseases such as cancer, diabetes and Alzheimer's disease.