发明名称 |
Process for producing 3-chloromethyl-3-cephem derivatives |
摘要 |
An industrially advantageous process for producing 3-chloromethyl-3-cephem derivative crystals. The process for 3-chloromethyl-3-cephem derivative production comprises: a first step in which a thiazolineazetidinone derivative (1) is reacted with a sulfonyl halide (2) in the presence of an acid in a solvent to obtain an azetidinone derivative (3); a second step in which the azetidinone derivative (3) is reacted with a chlorinating agent in an organic solvent to obtain a chlorinated azetidinone derivative (4); and a third step in which the chlorinated azetidinone derivative (4) is reacted with an alcoholate (5) at a pH of 8 or lower in a solvent comprising an alcohol and an ether and a 3-chloromethyl-3-cephem derivative (6) is recovered in the form of crystals.
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申请公布号 |
US7507812(B2) |
申请公布日期 |
2009.03.24 |
申请号 |
US20060570248 |
申请日期 |
2006.03.02 |
申请人 |
NIPPON CHEMICAL INDUSTRIAL CO., LTD. |
发明人 |
MATSUMOTO NOBUO;KAWAKABE HIROSHI;MANABE YASUKO |
分类号 |
C07D501/08;C07D501/10;C07D501/24 |
主分类号 |
C07D501/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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