发明名称 |
Catalytic anti-factor VIII allo-antibodies |
摘要 |
A method is disclosed of determining the presence of catalytic anti-Factor VIII allo-antibodies capable of degrading Factor VIII in a mammal, and of characterising the cleavage sites in said Factor VIII molecule by said catalytic anti-Factor VIII allo-antibodies. It also relates to an anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor; and to a pharmaceutical composition comprising said catalytic anti-Factor VIII allo-antibodies which are capable of degrading Factor VIII and which originate from said method of determination; and further to a pharmaceutical composition comprising said anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor. Finally, the present invention relates to the application in therapeutics of said anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor, of a pharmaceutical composition comprising said catalytic anti-Factor VIII allo-antibodies which are capable of degrading Factor VIII and which originate from said method of determination, and of a pharmaceutical composition comprising said anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor.
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申请公布号 |
US7507540(B1) |
申请公布日期 |
2009.03.24 |
申请号 |
US20000031938 |
申请日期 |
2000.07.18 |
申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);BAYER PHARMA |
发明人 |
KAVERI SRINIVAS;LACROIX-DESMAZES SEBASTIEN;KAZATCHKINE MICHEL |
分类号 |
G01N33/483;G01N33/53;A61K31/185;A61K35/14;A61K38/00;A61K38/08;A61K38/43;A61K39/395;A61K45/00;A61P7/00;A61P7/04;B01J20/281;C07K7/06;C07K14/755;C07K16/18;C12N5/06;C12N9/00;C12P21/04;C12Q1/26;G01N27/447;G01N30/88;G01N33/15;G01N33/50;G01N33/68;G01N33/86 |
主分类号 |
G01N33/483 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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