发明名称 NOV protein: an anti-angiogenic agent and its use, in particular for the treatment of cancer
摘要 The present invention relates to the use of a protein characterized in that it comprises or is constituted by the NOV protein, represented by the sequence SEQ ID NO: 2, or a fragment of this protein, providing that this fragment exhibits an angiogenesis-inhibiting activity, or any sequence derived from the sequence SEQ ID NO: 2 or from a fragment defined above, providing that this derived sequence exhibits an angiogenesis-inhibiting activity, or any sequence homologous to the sequence SEQ ID NO: 2 or to a fragment defined above, providing that this homologous sequence exhibits an angiogenesis-inhibiting activity, for the preparation of a medicament intended for the treatment of pathologies requiring the inhibition of endothelial proliferation or of pathologies requiring the inhibition of endothelial activation.
申请公布号 US7507712(B2) 申请公布日期 2009.03.24
申请号 US20040566679 申请日期 2004.07.30
申请人 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) 发明人 PLOUET JEAN;LAURENT-BEUBRY MARYVONNE;MARTINERIE-KRYCEVE CECILE
分类号 A61K38/16;A61K38/17;A61K38/18;A61P9/00;A61P17/00;A61P19/02;A61P27/02;A61P35/00;A61P37/00;A61P37/06;C07K14/435;C07K14/475 主分类号 A61K38/16
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