发明名称 |
THERAPEUTIC USE OF POLYMERS |
摘要 |
An insoluble polymer is deposited in a body cavity for instance to embolise a vein or pack an aneurysm, the polymer having pendant zwitterionic groups to improve biocompatibility. The insoluble polym er is preferably formed by an in situ gelling step in which a charged, preferably soluble, polymer having pendant zwitterionic groups is introduced in the form of a composition in which it is soluble and is gelled by being mixed with a counterionically charged soluble polymer (polyelectrolyte), to form a polyion complex. Preferably the or each soluble polymer is formed by polymerising ethylenically unsature d monomers including a zwitterionic monomer, for instance 2-methacryloyloxyethyl-2'-trimethylammoniumethyl phosphate inner salt, an ionic monomer such as trimethylammonium alkyl(alk)acrylate or a sulphoalkyl(alk)acrylate and optionally a diluent monomer such as an alkyl(alk)acrylate.
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申请公布号 |
CA2346863(C) |
申请公布日期 |
2009.03.17 |
申请号 |
CA19992346863 |
申请日期 |
1999.11.12 |
申请人 |
BIOCOMPATIBLES UK LIMITED |
发明人 |
STRATFORD, PETER WILLIAM;LEWIS, ANDREW LENNARD;COURT, JANE LOUISE |
分类号 |
A61K47/30;A61B17/00;A61B17/12;A61F2/06;A61K31/74;A61K31/80;A61K49/04;A61L27/14;A61P9/00;A61P9/14;C08F12/04;C08F16/14;C08F20/10;C08F22/40;C08F30/02 |
主分类号 |
A61K47/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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