发明名称 |
Integrin linked kinase modulation of monocyte activation |
摘要 |
Methods are provided to specifically modulate the activation of monocytes and/or macrophages. Administration of integrin linked kinase (ILK) blocking agents; compounds that otherwise prevent the binding of natural ILK ligands to ILK; or compounds that prevent expression of, or signaling through ILK exert an anti-inflammatory effect by inhibiting iNOS and COX-2 expression, at the level of transcription by suppressing the activation of NF-kappaB. The modulation of activation through ILK is used to regulate immune processes at targeted sites, for example to decrease undesirable inflammatory responses.
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申请公布号 |
US7504228(B2) |
申请公布日期 |
2009.03.17 |
申请号 |
US20020163599 |
申请日期 |
2002.06.05 |
申请人 |
QLT INC. |
发明人 |
KOJIC LJILJANA;LOGAN PATRICIA M.;WHEELER JEFFERY J.;SUTTON KYMBERLEY L.;KALMAR GABRIEL BELA |
分类号 |
G01N33/00;A61K31/00;A61K31/415;A61K31/44;A61K31/47;A61K33/26;A61K38/45;A61K39/395;C12N9/12;C12Q1/68;G01N33/53 |
主分类号 |
G01N33/00 |
代理机构 |
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