发明名称 |
Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders |
摘要 |
Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder mediated by CB1 receptors such as obesity: Formula (I) wherein: R1 and R2 are independently selected from aryl; and R3 is hydrogen or alkyl; or a pharmaceutically acceptable salt or prodrug thereof, wherein at least one of R1 and R2 has a non-hydrogen substituent in the ortho-position(s) thereof relative to the point of attachment to the [-CH-O-] group.
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申请公布号 |
US7504522(B2) |
申请公布日期 |
2009.03.17 |
申请号 |
US20040552575 |
申请日期 |
2004.04.29 |
申请人 |
VERNALIS RESEARCH LIMITED |
发明人 |
DAVIDSON JAMES EDWARD PAUL;DAWSON CLAIRE ELIZABETH;HARRISON KERRY;MANSELL HOWARD LANGHAM;PRATT ROBERT MARK;SOHAL SUKHJIT;RUSTON VICTORIA JANE |
分类号 |
C07D205/00;A61K31/397;A61P3/04;C07D205/04;C07D405/12;C07D409/12 |
主分类号 |
C07D205/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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