3-O-[beta-D-GLUCOPYRANOSYL(1->4)-alpha-L-ARABINOPYRANOSYL] -HEDERAGENIN INCREASING TRANSDUCING ACTIVITY OF CELL TRANSDUCING FUSION PROTEIN

摘要

A 3-O-(beta-D-glucopyranosyl(1->4)-alpha-L-arabinopyranosyl)-hederagenin is provided to be applied to aiding agent, medicine, cosmetic material increasing infiltration efficiency of the cell permeability fusion protein including Tat-SOD etc. and various disease treating field. A 3-O-(beta-D-glucopyranosyl(1->4)-alpha-L-arabinopyranosyl)-hederagenin improves cell permeation rate of cell permeability fusion protein. The cell permeability fusion protein is formed by covalent bonding HIV-Tat(49-57) consisting of 6~15 amino acids, oligolysine, oligoarginine, oligo(lysine and arginine), protein transport domain selected from PEP-1 and cell non-porous protein. The cell permeability fusion protein is HIV-Tat-Cu,Zn superoxide dismutase. The 3-O- (beta-D-glucopyranosyl(1->4)-alpha-L-arabinopyranosyl)-hederagenin is separated from Fatsia japonica.