| 摘要 |
. A represents a phenyl, a heteroaryl or a (C4-C8)cycloalkyl group, . Q represents an oxygen atom or a-CH2-link, . X, Y and Z represent carbon or nitrogen atoms, . R1 and R2 are chosen among: hydrogen, halogen, hydroxyl, cyano, oxo,-CF3, (C1-C6)alkyl, AIk, (C1-C6)alkoxy, (C1-C6)alkyl-O-(C1-C6)alkyl,-0-(C1-C6)alkyl-0-(C1-C6)alkyl, (C3-C8)cycloalkyl,-O-(C3-C8)cycloalkyl,-(CH2)m-SO2-(C1-C6)alkyl, benzyl, pyrazolyl,-CH2-triazolyl optionally substituted and-L-R12, wherein L represents a bond or a-CH2-and/or-CO-and/or,-SO2-linkage and R12 represents a (C3-C8)cycloalkyl or a group of formula (a), (b), (c), (c7), (d) or (e); . R3 represents a linear (C1-C10)alkyl group which is optionally substituted, . R4 represents a hydrogen or halogen atom or a hydroxyl, cyano, (C1-C6)alkyl or (C1-C6)alkoxy group, . R5 and R6 represent, independently one from the other, a hydrogen or halogen atom or a (C1-C5)alkyl group, or together form a (C3-C6)cycloalkyl group, . R7 and R8 represent a hydrogen atom or a (C1-C5)alkyl group, or together form a (C3-C6)cycloalkyl group, . R9 and R10 represent a hydrogen atom or a hydroxyl,-CO-(CI-C6)alkyl or-COO-(CI-C6)alkyl group, or together form a linear (C2-C3)alkylene chain, . R11 represents a hydrogen atom or an alkyl or cycloalkyl group, Processes for its preparation, its use in therapeutic and pharmaceutical preparations comprising it.
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