Processes for the preparation of cyclopropanecarboxylic acid and derivatives thereof

摘要

The present invention provides a process for the preparation of cyclopropanecarboxamide which comprises the steps of: (1) contacting cyclopropanecarboxylic acid with ammonia in a reactor at a temperature of 200 to 260 DEG C and a pressure of 10 to 100 bar absolute in the absence of both a catalyst and a solvent to form a melt of cyclopropanecarboxamide; (2) venting the reactor at a temperature above the melting point of cyclopropanecarboxamide to reduce the pressure to atmospheric pressure and remove excess ammonia and water of reaction from the cyclopropanecarboxamide; and (3) obtaining from the reactor cyclopropanecarboxamide essentially free of water and ammonia.