发明名称 |
GLUCAGON-LIKE PEPTIDE-1 DERIVATIVES AND THEIR PHARMACEUTICAL USE |
摘要 |
The invention relates to protracted Glucagon-Like Peptide-1 (GLP-1) derivatives and therapeutic uses thereof. The GLP-1 derivative of the invention comprises a modified GLP-1(7-37) sequence having a total of 2-12 amino acid modifications, including Glu22 and Arg26, and being derivatised with an albumin binding residue or pegylated in position 18, 20, 23, 30, 31, 34, 36, 37, or 39. These compounds are useful in the treatment or prevention of diabetes type 2 and related diseases. The compounds are potent, stable, have long half-lives, a high affinity of binding to albumin, and/or a high affinity of binding to the extracellular domain of the GLP-1 receptor (GLP-1R), all of which is of potential relevance for the overall aim of achieving long-acting, stable and active GLP-1 derivatives with a potential for once weekly administration. |
申请公布号 |
WO2009030738(A1) |
申请公布日期 |
2009.03.12 |
申请号 |
WO2008EP61755 |
申请日期 |
2008.09.05 |
申请人 |
NOVO NORDISK A/S;PETTERSSON, INGRID;SPETZLER, JANE;SCHAEFFER, LAUGE;LAU, JESPER;KRUSE, THOMAS;GARIBAY, PATRICK WILLIAM;RUNGE, STEFFEN;THOEGERSEN, HENNING |
发明人 |
SPETZLER, JANE;SCHAEFFER, LAUGE;LAU, JESPER;KRUSE, THOMAS;GARIBAY, PATRICK WILLIAM;RUNGE, STEFFEN;THOEGERSEN, HENNING |
分类号 |
C07K14/605;A61K38/26 |
主分类号 |
C07K14/605 |
代理机构 |
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