发明名称 |
GENE KNOCKOUT MESOPHILIC AND THERMOPHILIC ORGANISMS, AND METHODS OF USE THEREOF |
摘要 |
One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce ethanol as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non- native gene encodes a first non-native enzyme involved in the metabolic production of ethanol. Another aspect of the invention relates to a process for converting lignocellulosic biomass to ethanol, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism. |
申请公布号 |
WO2008141174(A3) |
申请公布日期 |
2009.03.12 |
申请号 |
WO2008US63237 |
申请日期 |
2008.05.09 |
申请人 |
MASCOMA CORPORATION;HOGSETT, DAVID, A.;RAJGARHIA, VINEET, B. |
发明人 |
HOGSETT, DAVID, A.;RAJGARHIA, VINEET, B. |
分类号 |
C07H21/02;C12N1/20;C12N15/00 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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