摘要 |
It is intended to provide a stent and a method for producing the same. The stent comprises a cylindrical stent main body having an outer surface and an inner surface, a first coating layer which coats at least the outer surface of the stent main body, and a second coating layer which substantially completely coats the first coating layer. The first coating layer is formed of a first composition which contains a polymer and an intimal hypertrophy inhibitor (preferably argatoroban) which does not inhibit the growth of endothelial cells, and in which a weight compositional ratio of the polymer to the intimal hypertrophy inhibitor is in the range of 8:2 to 3:7 (polymer : intimal hypertrophy inhibitor). The second coating layer is formed of a polymer alone or a second composition which contains a polymer and a drug, and in which a weight compositional ratio of the drug to 80% by weight of the polymer is less than 20% by weight. Further, a method of controlling a release rate of argatoroban from an argatoroban-carrying stent of the invention is provided. |
申请人 |
JAPAN STENT TECHNOLOGY CO., LTD.;TOKAI UNIVERSITY EDUCATIONAL SYSTEM;TOYO ADVANCED TECHNOLOGIES CO., LTD.;IWATA, HIROO;OMURA, IKUO;JIN, ZHEN YU;YAMASHITA, SHUZO;MOCHIZUKI, AKIRA |
发明人 |
IWATA, HIROO;OMURA, IKUO;JIN, ZHEN YU;YAMASHITA, SHUZO;MOCHIZUKI, AKIRA |