EPHRIN-EPH RECEPTOR SIGNAL TRANSMISSION CONTROL AGENT AND MOUSE HAVING ABNORMALITY IN EPHRIN-EPH RECEPTOR SIGNAL TRANSMISSION MECHANISM

摘要

PROBLEM TO BE SOLVED: To provide a medicine for controlling an ephrin-Eph receptor signal transmission mechanism to control the elongation of an axon on neurotization, and to provide a mouse having an abnormality in the ephrin-Eph receptor signal transmission mechanism. SOLUTION: An axon elongation control agent contains a medicine for promoting or inhibiting the function ofα-chimerin. Miffy mouse originated from B6 mouse exhibits an autosomal recessive inheritance related to a character which exhibits a gait abnormality walking in a state that right and left front and back legs are arranged, and has an abnormality inα-chimerin gene. COPYRIGHT: (C)2009,JPO&INPIT