A METHOD FOR PREPARATION OF SUBSTITUTED ADAMANTYLARYLMAGNESIUM HALIDES
摘要
The present invention concerns fine organic synthesis, particularly the method for preparing of substituted adamantylarylmagnesium halides. The known methods for preparing Grignard's reagent from substituted adamantylarylhalide give very low yeld of the desired product. Substituted adamantylarylhalides are active intermediates that by interacting with various electrophiles provide for a wide range of biologically active compounds. The aim of current invention was to develop a method for preparing substituted adamantylarylmagnesium halides. The aim was attained adding lithium chloride in the Grignard's reagent synthesis by acting on magnesium metal in dry tetrahydrofuran under argon by substituted adamantylarylhalide. It was demonstrated that adding lithium chloride to adamantylarylhalide within a range from 1:1 to 1:2 provides for stable high yield of the desired end product.
申请公布号
WO2008080993(A3)
申请公布日期
2009.03.12
申请号
WO2007EP64648
申请日期
2007.12.28
申请人
KALVINSH, IVARS;TRIBULOVICH, VYACHESLAV;LABEISH, VLADIMIR;CHERNOBROVIJS, ALEKSANDRS
发明人
KALVINSH, IVARS;TRIBULOVICH, VYACHESLAV;LABEISH, VLADIMIR;CHERNOBROVIJS, ALEKSANDRS