发明名称 |
BONE MORPHOGENETIC PROTEIN (BMP)-BINDING DOMAINS OF PROTEINS OF THE REPULSIVE GUIDANCE MOLECULE (RGM) PROTEIN FAMILY AND FUNCTIONAL FRAGMENTS THEREOF, AND USE OF SAME |
摘要 |
<p>The present invention relates to the identification and use of bone morphogenetic protein (BMP)-binding domains of members of the repulsive guidance molecule (RGM) protein family, and polypeptide fragments and fusion proteins derived therefrom. The domains, i.e., peptide fragments and fusion proteins, according to the invention are suitable as agents for the active or passive immunization of individuals, or as diagnostic and therapeutic agents for use for diseases or medical conditions in whose origin or progression a member of the RGM family and a cellular receptor associated with this molecule, such as neogenin and/or BMP in particular, is involved. The invention further relates to monoclonal and polyclonal antibodies directed against the binding domains according to the invention, and against the polypeptides derived therefrom, and to methods for producing the polypeptides, fusion proteins, and antibodies according to the invention.</p> |
申请公布号 |
WO2009030500(A1) |
申请公布日期 |
2009.03.12 |
申请号 |
WO2008EP07339 |
申请日期 |
2008.09.08 |
申请人 |
ABBOTT GMBH & CO. KG;MUELLER, BERNHARD;SCHAFFAR, GREGOR;MEYER, AXEL;SCHMIDT, MARTIN |
发明人 |
MUELLER, BERNHARD;SCHAFFAR, GREGOR;MEYER, AXEL;SCHMIDT, MARTIN |
分类号 |
C07K14/705;C07K16/28 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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