<p>Methods of thermally inactivating a rotavirus are provided according to the present invention which include exposing the rotavirus to a temperature in the range of about 50°C - 80°C, inclusive, for an incubation time sufficient to render the rotavirus incapable of replication or infection. The thermally inactivated rotavirus is antigenic and retains a substantially intact rotavirus particle structure. Vaccine compositions and methods of vaccinating a subject against rotavirus are provided which include generation and use of thermally inactivated rotavirus.</p>
申请公布号
CA2698392(A1)
申请公布日期
2009.03.12
申请号
CA20082698392
申请日期
2008.09.04
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SE CRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
JIANG, BAOMING;GLASS, ROGER I.;SALUZZO, JEAN-FRANCOIS