MODIFIED POLYMERASES AND ATTENUATED VIRUSES AND METHODS OF USE THEREOF
摘要
Compositions and methods involving modified viral polymerases with one or more substitutions of different amino acids at conserved regions of the polymerase result in enzymes with varying rates and fidelity of replication A universally applicable polymerase mechanism based strategy for the production of attenuated viruses and anti-viral vaccines is also disclosed
申请公布号
WO2008140622(A3)
申请公布日期
2009.03.12
申请号
WO2007US88775
申请日期
2007.12.24
申请人
THE PENN STATE RESEARCH FOUNDATION;CAMERON, CRAIG, E.;ARNOLD, JAMIE;CASTRO, CHRISTIAN
发明人
CAMERON, CRAIG, E.;ARNOLD, JAMIE;CASTRO, CHRISTIAN