| 发明名称 |
Use of compounds that inhibit the EF-Tu-nucleolin interaction for preventing or treating tularemia |
| 摘要 |
<p>The present invention relates to the use of an inhibitor of the interaction between the bacterial elongation factor Tu (EF-Tu) of Francisella tularensis and nucleolin for the manufacture of a medicament for preventing or treating tularemia. The invention further provides a method for screening compounds useful for preventing or treating tularemia, comprising contacting a compound with EF-Tu of F. tularensis and human nucleolin or the RGG domain of nucleolin.</p> |
| 申请公布号 |
EP2033655(A1) |
申请公布日期 |
2009.03.11 |
| 申请号 |
EP20070301337 |
申请日期 |
2007.09.04 |
| 申请人 |
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) |
发明人 |
BAREL, MONIQUE;CHARBIT, ALAIN;HOVANESSIAN, ARA;BRIAND, JEAN-PAUL |
| 分类号 |
A61K38/10;A61K38/02;A61K39/09;A61K39/395;A61P31/04;C07K7/00;C12Q1/00 |
主分类号 |
A61K38/10 |
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