REMEDIES FOR SEPSIS

摘要

Treatment for sepsis involves administration of an opioid kappa receptor agonist. ACTIVITY : Antibacterial; Immunosuppressive; Hypertensive; Anticoagulant; Thrombolytic. In a lipopolysaccharide induced toxemia model in ICR mice, administration of (-)-17-(cyclopropylmethyl)-3,14-beta -dihydroxy-4,5alpha -epoxy-6-beta -[N-methyl-trans-3-(3-furyl)acrylamido]morphinane hydrochloric acid salt at 100 Microg orally increased the percentage of mice surviving after 24 hours from 30% for a control, to 80%. The corresponding values after 48 hours were 10% and 40% respectively. MECHANISM OF ACTION : Opioid Agonist-Kappa.