发明名称 ANTI-INFLUENZA DRUGS
摘要 Agent useful for treating influenza comprises ambroxol and bromhexine or their salts ACTIVITY : Virucide. Mice infected with influenza virus were treated with 30 mg/kg/day of ambroxol. After 4 days, levels of cytokines in fluids was 19.2 (28.9) for tumor necrosis factor-alpha; 118.6 (184.7) for interleukin 12; 10.2 (7.1) for interferon-gamma; and 433.5 (216.2) for interleukin 6. (Results in brackets are for untreated controls; the figures except for interferon-gamma are significant at P(0.02)). MECHANISM OF ACTION : Protease, Immunoglobulin A (IgA) and Immunoglobulin G (IgG) Promoter; Cytokine Inhibitor.
申请公布号 EP1437134(A4) 申请公布日期 2009.03.11
申请号 EP20020762982 申请日期 2002.09.03
申请人 BOEHRINGER INGELHEIM INTERNATIONAL GMBH;TECHNO NETWORK SHIKOKU CO., LTD. 发明人 KIDO, HIROSHI
分类号 A61K31/137;A61P31/16;A61P43/00 主分类号 A61K31/137
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