发明名称 |
Improved process for manufacture of 4-amino-hydroxybutylidene-1,1-bisphosphonic acid and its salts |
摘要 |
<p>Disclosed herein is a cost effective, high yielding, reproducible method for the manufacture of alendronic acid or its salt such as sodium alendronate from inexpensive and readily available pyrrolidone using phosphonating agents such as PCl 3 in the presence of acids such as sulphonic acids, sulphuric acid or phosphoric acid.</p> |
申请公布号 |
EP1803727(B1) |
申请公布日期 |
2009.03.11 |
申请号 |
EP20060126565 |
申请日期 |
2006.12.19 |
申请人 |
IPCA LABORATORIES LIMITED |
发明人 |
KUMAR, ASHOK;DIKE, SUNEEL YESHWANT;NIJASURE, AVINASH MANOHAR;BHAWARE, VIJAYA |
分类号 |
C07F9/38;A61K31/663 |
主分类号 |
C07F9/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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