SUBSTITUTED BIPHENYL CARBOXYLIC ACIDS AND DERIVATIVES THEREOF.

摘要

The present invention relates to compounds having the general Formula (I) with the definitions of X, Y, R1, R2, R3, R4 R9, and R10, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of gamma-secretase activity, wherein A is O, NH, S; X is a bond or a group -CR5R6 Upsilon is a carboxy group -C(O)OH or a substituted or unsubstituted tetrazole group..