发明名称 Malonamides as orexin antagonists
摘要 The present invention relates to compounds of formula I wherein Ar1, Ar2, R, R1, R2, R3 and n are as defined herein or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved like sleep disorders.
申请公布号 US7501541(B2) 申请公布日期 2009.03.10
申请号 US20080044002 申请日期 2008.03.07
申请人 HOFFMANN-LA ROCHE INC. 发明人 GOBBI LUCA;KNUST HENNER;MALHERBE PARICHEHR;NETTEKOVEN MATTHIAS;PINARD EMMANUEL;ROCHE OLIVIER;ROGERS-EVANS MARK
分类号 C07C233/05;A61K31/65 主分类号 C07C233/05
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