发明名称 |
ГЛЮКУРОНИДИРОВАННЫЕ МЕТАБОЛИТЫ НЕБИВОЛОЛА |
摘要 |
This invention provides glucuronidated nebivolol metabolites and pharmaceutical compositions of glucuronidated nebivolol metabolites for treatment of cardiovascular diseases. In addition, this invention also provides compositions comprising nebivolol and/or at least one glucuronidated metabolite of nebivolol and/or at least one other active compound in a pharmaceutically acceptable carrier. This invention also provides methods of treating and/or preventing vascular diseases, by administering at least one glucuronidated metabolite of nebivolol that is capable of releasing a therapeutically effective amount of nitric oxide to a targeted site affected by the vascular disease. Also, this invention is directed to the treatment and/or prevention of migraine headaches administering at least one glucuronidated metabolite of nebivolol. This invention may also be used in conjunction with or as a single treatment of metabolic syndrome disorders. |
申请公布号 |
RU2007132727(A) |
申请公布日期 |
2009.03.10 |
申请号 |
RU20070132727 |
申请日期 |
2006.01.30 |
申请人 |
МИЛАН ЛЭБОРЕТЕРИЗ, ИНК. (US) |
发明人 |
О&grave,ДОННЕЛЛ Джон П. (US);ОУЭНС Уолтер (US);ДАНКАН Джозеф (US);ШО Эндрю (US) |
分类号 |
A61K31/70 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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