发明名称 POLYMORPHYSM OF DODECAHYDROCYCLOPENTA[A]PHENANTRENYL ETHER OF THIOPHENECARBOXYLIC ACID
摘要 FIELD: chemistry. ^ SUBSTANCE: invention concerns crystalline form A of compound of the formula I, method of its obtainment and application in medicine. Form A can be obtained by crystallisation of compound of the formula I from solution in isopropanol, ethylacetate, n-butanol, hexane, heptane, tertbutylmethyl ether, toluene or tetrahydrofurane, and features melting point at 264°C along with degradation at heating rate of 20°C/minute by data of differential scanning calorimetry, and diffraction bands (2theta at angular degrees ±0.2°): 3.6°, 7.3°, 13.4°, 14.6°, 18.3°, 22.0°, 25.8°, 25.9° and 29.5°, according to the data of x-ray structural analysis. . ^ EFFECT: obtaining stable form of compound of the formula I with anti-inflammation effect. ^ 4 cl, 5 ex, 7 tbl
申请公布号 RU2348646(C1) 申请公布日期 2009.03.10
申请号 RU20070143025 申请日期 2003.07.28
申请人 NOVARTIS AG 发明人 JORDINE GUIDO;MUTTS MIKHAEHL'
分类号 C07J33/00;A61K31/58;A61P11/00 主分类号 C07J33/00
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