| 摘要 |
NOVEL 4-AMINOPYRIMIDINE-5-ONE DERIVATIVES OF THE FORMULA FOR. 1 WHEREIN R1 AND R2 ARE AS DEFINED IN THE SPECIFICATION, ARE DISCLOSED. THESE COMPOUNDS INHIBIT CYCLIC-DEPENDENT KINASES, IN PARTICULAR CYCLIN-DEPENDENT KINASE 4 (CDK4). THESE COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND ESTERS HAVE ANTIPROLIFERATIVE ACTIVITY AND ARE USEFUL IN THE TREATMENT OR CONTROL OF CANCER, IN PARTICULAR SOLID TUMORS. THIS INVENTION IS ALSO DIRECTED TO PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, THEIR USE FOR TREATING OR CONTROLLING CANCER, TO A PROCESS OF THEIR PREPARATION AND TO INTERMEDIATES USEFUL IN THEIR PREPARATION.
|
