| 摘要 |
The present invention relates to a composition for transdermal delivery comprising a drug-containing layer that comprises gestodene or an ester thereof and a carrier selected from the group consisting of polyisobutylenes, polybutenes, polyisoprenes, polystyrenes, styrene isoprene styrene block polymers, styrene butadiene styrene block polymers and mixtures thereof, wherein the drug-containing layer has a solubility for said gestodene of no more than 3% by weight of the drug-containing layer. The gestodene or an ester thereof is in an amount ranging between 0.5 and 3% by weight of the drug-containing layer. A patch comprising a drug-containing layer with low content of hormones, such as gestodene, and optionally an estrogen (e.g. ethinyl estradiol) is the most representative. Upon administering the patch to a woman, plasma levels of at least 1.0 ng/ml of gestodene is achieved at steady state conditions without the need of incorporating penetration enhancers or permeation enhancers in the drug-containing layer. Satisfactorily plasma levels of the hormones is also achieved throughout a period of at least 1 week, making the patch applicable for being used in female contraception with the concept of administering the patch ones weekly. |
