| 摘要 |
<p>The present invention is thus directed to coating compositions and methods of their use, and to the objects coated therewith, for their use as implants and medical devices In particular, the medical devices and implants of the present invention comprise biomatepals which are coated with functionalized polymers having biomolecules conjugated thereto, or with the functionalized polymers to which such biomolecules can be conjugated to form the biofunctionalized polymer The biomolecules attached to the functionalized polymers contemplated herein may be defined as natural or synthetic chemical compounds which possess an ability to covalently bond to the functional group on the functionalized polymer or a spacer thereon, preferably via a sulfhydryl group thereon The functionalized or biofunctionalized polymers of the present invention may comprise spacer molecules which are covalently linked via sulfhydryl binds to the functional groups thereof for linking to the biomolecules of the biofunctionalized polymers.</p> |
