COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATION AND STROKE
摘要
Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP inhibition. Therapeutic applications are relevant for preventing or inhibiting neurological cell death for a variety of neurodegenerative conditions including Parkinson's disease, ischemia, and stroke. Also disclosed is a high-throughput screen for identifying compounds capable of inhibiting PARG and/or PARP.
申请公布号
WO2007014226(A3)
申请公布日期
2009.02.26
申请号
WO2006US28894
申请日期
2006.07.26
申请人
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;HERGENROTHER, PAUL, J.;PUTT, KARSON, S.;LIU, XIANJUN