发明名称 |
GRADIENT INJECTION FOR BIOSENSING |
摘要 |
A single injection gradient with a biosensor, both structural and methodological, achieves the binding of analyte to immobilized ligand over a wide concentration range without the necessity of regeneration of the sensing area. A gradient of concentrations adjacent to or within a flow cell facilitates kinetic analysis of interactions without requiring multiple discrete volumes or injections to achieve a range of concentrations. A continuous gradient fluid is preferably formed directly adjacent to the flow cell inlet or a region of sample/buffer dispersion at an injection point into a flow channel of a flow cell. The analyte gradient may be flowed through the flow cell from a low analyte concentration. Multiple component gradients are also provided. |
申请公布号 |
WO2009025680(A1) |
申请公布日期 |
2009.02.26 |
申请号 |
WO2008US00547 |
申请日期 |
2008.01.16 |
申请人 |
NOMADICS, INC.;QUINN, JOHN, GERARD |
发明人 |
QUINN, JOHN, GERARD |
分类号 |
G01N35/08 |
主分类号 |
G01N35/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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