发明名称 |
Multi-armed, monofunctional, and hydrolytically stable derivatives of poly (ethylene glycol) and related polymers for modification of surfaces and molecules |
摘要 |
Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O-(CH2CH2O)nCH2CH2- wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.
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申请公布号 |
US2009054590(A1) |
申请公布日期 |
2009.02.26 |
申请号 |
US20080284357 |
申请日期 |
2008.09.20 |
申请人 |
NEKTAR THERAPEUTICS AL, CORPORATION |
发明人 |
HARRIS J. MILTON;VERONESE FRANCESCO MARIA;CALICETI PAOLO;SCHIAVON ODDONE |
分类号 |
C08L89/00;A61K47/48;C08G63/00;C08G65/00;C08G65/329;C08G69/26;C08G73/10 |
主分类号 |
C08L89/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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