IDENTIFICATION AND USE OF PEPTIDE INHIBITORS OF PROTEIN SYNTHESIS
摘要
The present invention discloses compositions of peptide inhibitors of protein synthesis, and methods of identifying peptide inhibitors that are capable of inhibiting protein synthesis through an interaction at a stem-loop H18 in 16S rRNA of a 30S ribosomal subunit. Screening methods for peptides are disclosed, in addition to methods of determining the affinity of a test compound for a ribosomal subunit.
申请公布号
WO2009026218(A2)
申请公布日期
2009.02.26
申请号
WO2008US73468
申请日期
2008.08.18
申请人
UNIVERSITY OF ILLINOIS;LLANO-SOTELO, BEATRIZ;MANKIN, ALEXANDER, S.;KLEPACKI, DOROTA