METHODS AND COMPOSITIONS FOR POST-TRANSCRIPTIONAL GENE SILENCING

摘要

An isolated double stranded ribonucleic acid (dsRNA) molecule that inhibits the expression of a target gene, the dsRNA comprising two strands of nucleotides wherein a first strand has a length of from 19 to 28 consecutive nucleotides and is substantially identical to a sequence in the target gene and wherein a second strand is substantially complementary to the first strand, and a binding moiety that binds a 3 ' end of the first strand to a 5 ' end of the second strand. An isolated double stranded ribonucleic acid molecule comprising a first strand of nucleotides that is substantially identical to SEQ ID NO: 3 and a second strand that is substantially complementary to the first.