| 摘要 |
<p>A male reproductive health screening panel is disclosed. In some embodiments, the method comprises screening human sperm using a sperm DNA accelerated decondensation (SDAD) Test, and/or a Sperm DNA decondensation (SDD) assay, in combination with an assessment of the sperm DNA fragmentation index (DFI) of the sperm sample of interest. The method is useful in the screening and clinical management for a reproductively challenged human couple, in the assessing the reproductive health of a potential sperm donor, and in selecting an appropriate assisted reproductive technique (ART) for a reproductively challenged couple. These methods provide a decision tree that employs a patient's sperm test results in a SDAD Test, sperm DFI and/or SDD Test. An automated scoring method is disclosed for assessing sperm activity after SDAD and SDD tests. Also disclosed is an automated sperm processing protocol for both the SDD and SDAD tests.</p> |
