发明名称 |
LOX AND LOXL2 INHIBITORS AND USES THEREOF |
摘要 |
The present application relates to anti-LOX and anti-LOXL2 antibodies and their use in purification, diagnostic and therapeutic methods. Antibodies include monoclonal antibodies, humanized antibodies and functional fragments thereof. Anti-LOX and anti-LOXL2 antibodies can be used to identify and treat conditions such as a fibrotic condition, angiogenesis, or to prevent a transition from an epithelial cell state to a mesenchymal cell state. |
申请公布号 |
US2009053224(A1) |
申请公布日期 |
2009.02.26 |
申请号 |
US20080185050 |
申请日期 |
2008.08.01 |
申请人 |
ARRESTO BIOSCIENCES |
发明人 |
SMITH VICTORIA;OGG SCOTT;VAN VLASSELAER PETER;BARRY VIVIAN E.;MARSHALL DEREK;HOLZER ALISON KAY;RODRIGUEZ HECTOR;OYASU MIHO;MCCAULEY SCOTT ALAN;GARCIA CARLOS AURELIO;TOKUOKA BIERMANN DONNA HIROKO |
分类号 |
A61K39/395;A61P9/00;A61P35/00;C07K16/00;C12N5/00;C12N9/99;G01N33/53 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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