| 发明名称 |
USE OF MGLUR5 ANTAGONISTS FOR THE TREATMENT OF GERD |
| 摘要 |
<p>The present invention relates to the pharmaceutical use of compounds of formula (I) wherein A, E, R1, R2, R2 and R4 are as defined in the specification, acting as antagonists of metabotropic glutamate type-5 receptors (mGluR5 receptor antagonists) for the treatment, prevention and/or delay of progression of gastro- esophageal reflux disease (GERD).</p> |
| 申请公布号 |
WO2009024491(A1) |
申请公布日期 |
2009.02.26 |
| 申请号 |
WO2008EP60509 |
申请日期 |
2008.08.11 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG;JAESCHKE, GEORG;KOLCZEWSKI, SABINE;SPOOREN, WILL;VIEIRA, ERIC |
发明人 |
JAESCHKE, GEORG;KOLCZEWSKI, SABINE;SPOOREN, WILL;VIEIRA, ERIC |
| 分类号 |
A61K31/4439;A61P1/04 |
主分类号 |
A61K31/4439 |
| 代理机构 |
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