| 发明名称 |
METALLO-beta-LACTAMASE INHIBITOR |
| 摘要 |
PROBLEM TO BE SOLVED: To provide a metallo-β-lactamase inhibitor which becomes a medicine inhibiting deactivation of aβ-lactam-based antibody substance and recovering antibacterial activity. SOLUTION: A maleic acid derivative having a structure represented by general formula (I) has a metallo-β-lactamase inhibiting activity. The combined use of the compound represented by the general formula (I) with aβ-lactam-based antibody substance enables recovery of antibacterial activity ofβ-lactam-based antibody substance to metallo-β-lactamase-producing bacterium. COPYRIGHT: (C)2009,JPO&INPIT
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| 申请公布号 |
JP2009040743(A) |
申请公布日期 |
2009.02.26 |
| 申请号 |
JP20070209054 |
申请日期 |
2007.08.10 |
| 申请人 |
MEIJI SEIKA KAISHA LTD |
发明人 |
MORINAKA AKIHIRO;CHIKAUCHI KEN;IDA MIZUYO;ABE TAKAO;HIRAIWA YUKIKO;KUDO TOSHIAKI |
| 分类号 |
A61K31/194;A61K31/222;A61K31/225;A61K31/341;A61K31/351;A61K31/40;A61K31/4164;A61K31/4406;A61K31/443;A61K31/445;A61K31/4453;A61K31/495;A61K31/5375;A61K31/695;A61K45/00;A61P31/04;A61P43/00;C07C57/13;C07C57/42;C07C57/48;C07C57/50;C07C59/42;C07C59/46;C07C59/52;C07C59/68;C07C63/307;C07C69/593;C07C69/618;C07C69/734;C07C233/65;C07C233/83;C07C235/06;C07C279/08;C07C323/54;C07D207/12;C07D211/46;C07D213/55;C07D233/22;C07D295/14;C07D295/18;C07D307/60;C07D307/62;C07D307/64;C07D309/08;C07D405/06;C07D407/04;C07F7/18 |
主分类号 |
A61K31/194 |
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