DETECTION AND TREATMENT OF SCHIZOPHRENIA

摘要

Disclosed is a schizophrenia detection method. Also disclosed is a schizophrenia detection reagent or apparatus for use in the method. Further disclosed is a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia comprises a carbonyl scavenger or an inhibitor of the production of a protein-modified product of a carbonyl compound as an active ingredient. The schizophrenia detection method is achieved by the step of measuring at least one item selected from the group consisting of the following items (1) to (4) in a subject: (1) the genetic abnormality of glyoxalase-I gene; (2) the expression level or activity of glyoxalase-I in a biological sample; (3) the quantity of a carbonyl compound or a protein-modified product thereof; and (4) and the quantity of pyridoxal in a biological sample.