发明名称 |
PROCESS FOR PRODUCING PHENYLALANINE DERIVATIVE HAVING QUINAZOLINEDIONE SKELETON AND INTERMEDIATE FOR THE SAME |
摘要 |
<p>The present invention provides a method for producing a phenylalanine derivative(s) having a quinazolinedione ring of formula (5), including steps comprising of: reacting an acylphenylalanine derivative(s) of formula (1) with a carbonyl group-introducing reagent(s) and a derivative(s) of anthranilic acid to form an asymmetric urea intermediate(s); making the asymmetric urea intermediate(s) into a quinazolinedione compound(s) of formula (4) in the presence of a base(s); and N-alkylating quinazolinedione ring amide of the obtained quinazolinedione compounds with N-alkylation agents. This production method is an industrially applicable method for producing phenylalanine derivatives having a quinazolinedione skeleton, which are compounds highly useful as drugs having alpha 4 integrin inhibiting activity. In the formulae (1) and (5), R1 represents a phenyl group having a substituent(s) and the like, R2 represents an alkyl group and the like, R3 represents a dialkylamino group and the like, and R4 represents an alkyl group and the like. <CHEM></p> |
申请公布号 |
EP1595870(A4) |
申请公布日期 |
2009.02.25 |
申请号 |
EP20040713193 |
申请日期 |
2004.02.20 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
KATAOKA, NORIYASU;TATARA, AKINORI;YATAGAI, MASANOBU;YAMANAKA, JUNKO |
分类号 |
C07C233/87;C07D239/96;(IPC1-7):C07D239/96;C07C275/42;C07C229/54 |
主分类号 |
C07C233/87 |
代理机构 |
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