发明名称 |
MEANS AND METHOD FOR INDUCING EXON-SKIPPING |
摘要 |
In the present invention means and method are provided for optimising exon-skipping using exon-internal AON. We show that skipping efficiencies are improved by targeting putative splicing regulatory sequences (ESEs) within an exon. Such double targeting may be particularly useful for exons with which efficient skipping was difficult to obtain prior to the invention. |
申请公布号 |
EP2027267(A1) |
申请公布日期 |
2009.02.25 |
申请号 |
EP20070729286 |
申请日期 |
2007.05.18 |
申请人 |
ACADEMISCH ZIEKENHUIS LEIDEN |
发明人 |
AARTSMA-RUS, ANNEMIEKE;VAN DEUTEKOM, JUDITH CHRISTINA THEODORA;VAN OMMEN, GARRIT-JAN BOUDEWIJN |
分类号 |
A61K31/7088;A61K31/7115;A61K48/00;C12N15/11 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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