发明名称 |
Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or Exendin-4 and uses thereof |
摘要 |
<p>The present invention relates to a population of insulin producing cells made by a process comprising contacting non-insulin producing cells with a growth factor selected from the group consisting of GLP-1 or Exendin-4, growth factors having amino acid sequences substantially homologous to GLP-1 or Exendin-4, and fragments thereof. The present invention also relates to methods of differentiating non-insulin producing cells into insulin producing cells and of enriching a population of cells for insulin-producing cells. The present invention also relates to methods of treating diabetes.</p> |
申请公布号 |
EP2028269(A1) |
申请公布日期 |
2009.02.25 |
申请号 |
EP20080019260 |
申请日期 |
1999.08.10 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
EGAN, JOSEPHINE;PERFETTI, RICCARDO;PASSANITI, ANTONIO;GREIG, NIGEL;HOLLOWAY, HAROLD |
分类号 |
A61K38/22;C12N15/09;A61K35/12;A61K35/39;A61K38/04;A61K38/26;A61P3/10;A61P5/50;C07K14/575;C07K14/605;C12N5/071;C12Q1/68;C12R1/91 |
主分类号 |
A61K38/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|