发明名称 |
Dominant negative PLB mutant for use in treating cardiac disease |
摘要 |
Methods for the delivery of genes to improve cardiac function including the use of viral vectors, isolation of the heart from systemic circulation, and induction of hypothermia/cardiac arrest are described. The method results in high-level, long-term expression of reporter genes and enhanced cardiac function in hamster models of heart disease. |
申请公布号 |
EP1317289(B1) |
申请公布日期 |
2009.02.25 |
申请号 |
EP20010971139 |
申请日期 |
2001.09.11 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CHIEN, KENNETH, R.;HOSHIJIMA, MASAHIKO;ROSS, JOHN, JR.;IKEDA, YASUHIRO |
分类号 |
A61K48/00;A61K38/17;A61K38/46;A61P9/00;C12N15/12 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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