发明名称 |
POLYPEPTIDE PRODUCING CELLS |
摘要 |
The current invention describes a nucleic acid comprising in a 5' to 3' direction a) a first nucleic acid encoding a heterologous polypeptide without an in frame stop codon, b) a second nucleic acid beginning with a 5' splice donor site and terminated by a 3' splice acceptor site comprising an in frame translational stop codon and a polyadenylation signal, and c) a nucleic acid encoding i) at least a fragment of a transmembrane domain, or ii) a signal peptide for a GPI-anchor. |
申请公布号 |
EP2027273(A1) |
申请公布日期 |
2009.02.25 |
申请号 |
EP20070725230 |
申请日期 |
2007.05.15 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
ENDL, JOSEF;KOPETZKI, ERHARD;PLOETTNER, OLIVER;SCHWARZ, URSULA;TIEFENTHALER, GEORG |
分类号 |
C07K16/00;C07K16/06;C12N15/85 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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